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KMID : 0603519970020020089
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Journal of Korean Association of Cancer Prevention
1997 Volume.2 No. 2 p.89 ~ p.101
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Anticarcinogenecity of Lactic Acid Bacteria
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Bae Hyoung-Suk
Baek Young-Jin
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Abstract
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This study was aimed to review recent reports on antitumor activity of lactic acid bacteria including the relationship among the gut microflora, nutritional factors and carcinogenesis in human and animals. The fecal bacterial enzymes, β -glucuronidase, nitroreductase, and azoreductase were shown to play an important role in the incidence of colon cancer. These enzyme activities in feces were increased on a Western (high fat and animal protein) diet, but reduced by consuming of 1∼3 × 1010 Lactobacilli per day. High consuming ( ≥ 225 g/day) of fermented milk products, even the people on a Western diet were epidemiologically revealed to be at low risk for colon and breast cancer. This antitumor effect is attributed to reducing the production of harmful bacterial enzymes such as β -glucuronidase, nitroreductase, and azoreductase due to decreasing of putrefactive bacteria in colon. In animal models having tumors, Lactobacilli cultures also significantly suppressed the growth of sarcoma, leukemia and carcinoma. The antitumor effects of lactic acid bacteria are supposed to be host-mediated and dependent on the activation of non-specific effector cells such as macrophages or natural killer cells.
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KEYWORD
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Lactic acid bacteria, Cancer, Antitumor, Fermented milk
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